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(2001) demonstrated that IGF-1 overexpression in mouse models resulted in 15-30% increases in muscle mass and strength

For malabsorption-related deficiency, including PA: lifelong intramuscular injections are currently the best known treatment, because they release B12 directly into the bloodstream

This allows for wide-reaching comparative studies between different types of animal models as well as comparisons with findings from human patient samples, all efforts that have been pointing the IVD research community toward better consensus on important topics such as the molecular basis of IVD development, maintenance, and degeneration, and molecular markers that define various cells and components within the IVD

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